Variations of Serum Carbonic Acid pk' With ph and Temperature

Abstract

Human and canine serum carbonic acid pk' was shown to vary inversely with ph as well as with temperature. At ph 7.4 and 37.5°C the accepted value should be lowered from 6.10 to 6.09. The rise in pk' for a 1.0 unit fall in ph was 0.044 at 37.5° and 0.063 at 24°. The rise in pk' for a 1°C fall in temperature was 0.0054 at ph 7.4 and 0.0063 at ph 6.8. A nomogram was constructed to define pk' for temperatures from 10° to 45°C, and for ph values from 6.6 to 8.0. Submitted on February 8, 1956