Human papillomavirus oncoproteins: pathways to transformation
Top Cited Papers
- 1 July 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Cancer
- Vol. 10 (8), 550-560
- https://doi.org/10.1038/nrc2886
Abstract
An association between human papillomavirus (HPV) infection and the development of cervical cancer was initially reported over 30 years ago, and today there is overwhelming evidence that certain subtypes of HPV are the causative agents of these malignancies. The p53 and retinoblastoma proteins are well-characterized targets of the HPV E6 and E7 oncoproteins, but recent studies have shown that the alteration of additional pathways are equally important for transformation. These additional factors are crucial regulators of cell cycle progression, telomere maintenance, apoptosis and chromosomal stability. Understanding how HPV oncoproteins modify these activities provides novel insights into the basic mechanisms of oncogenesis.Keywords
This publication has 159 references indexed in Scilit:
- Oncogenic activities of human papillomavirusesVirus Research, 2009
- Atypical E2Fs: new players in the E2F transcription factor familyTrends in Cell Biology, 2009
- Papillomavirus E6 proteinsVirology, 2009
- The human papillomavirus E7 oncoproteinVirology, 2009
- Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexesVirology, 2008
- DNA damage checkpoints: from initiation to recovery or adaptationCurrent Opinion in Cell Biology, 2007
- Association of E6AP (UBE3A) with human papillomavirus type 11 E6 proteinVirology, 2007
- Modulation of apoptosis by human papillomavirus (HPV) oncoproteinsArchiv für die gesamte Virusforschung, 2006
- Papillomaviruses and cancer: from basic studies to clinical applicationNature Reviews Cancer, 2002
- The Hallmarks of CancerCell, 2000