Protein S abnormalities: A diagnostic nightmare
- 26 April 2011
- journal article
- review article
- Published by Wiley in American Journal of Hematology
- Vol. 86 (5), 418-421
- https://doi.org/10.1002/ajh.21992
Abstract
Heterozygous deficiency of Protein S (PS) increases the risk for developing thrombosis. Many acquired conditions alter plasma PS levels. These complex interactions of PS in plasma make it imperative that clinical PS assay limitations are understood so that the assays are reliable, reproducible and specific to diagnose true genetic abnormalities based on plasma phenotype alone. Unfortunately, the diagnosis of PS deficiency is difficult and complicated. Three basic assays can be utilized for assessing PS in plasma: PS activity assay, Free PS antigen assay, and Total PS antigen assay. This article will review these clinical assays and their associated problems. We also discuss the confounding and interfering factors that make it difficult to obtain an accurate diagnosis of PS deficiency. Am. J. Hematol. 86:418–421, 2011.Keywords
This publication has 19 references indexed in Scilit:
- Haemostatic reference intervals in pregnancyThrombosis and Haemostasis, 2010
- Clinical relevance of decreased free protein S levels: results from a retrospective family cohort study involving 1143 relativesBlood, 2009
- Inhibitors and activation markers of the haemostatic system during hormone therapy: A comparative study of oral estradiol (2 mg)/ dydrogesterone and estradiol (2 mg)/ trimegestoneThrombosis and Haemostasis, 2008
- Stability of coagulation assays performed in plasma from citrated whole blood transported at ambient temperatureThrombosis and Haemostasis, 2008
- Use of a functional assay to diagnose protein S deficiency; inappropriate testing yields equivocal resultsInternal Medicine Journal, 2007
- Emerging Technologies and Quality Assurance in Hemostasis: A Review of Findings from the Royal College of Pathologists of Australasia Quality Assurance ProgramSeminars in Thrombosis and Hemostasis, 2007
- Molecular basis of protein S deficiencyThrombosis and Haemostasis, 2007
- Performance goals for the laboratory testing of antithrombin, protein C and protein SThrombosis and Haemostasis, 2006
- The anticoagulant protein C pathwayFEBS Letters, 2005
- Normal Functional Protein S Activity Does Not Exclude Protein S DeficiencyPathophysiology of Haemostasis and Thrombosis, 2003