The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia
- 1 March 2009
- journal article
- review article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 66 (3), 300-305
- https://doi.org/10.1001/archneurol.2009.27
Abstract
In recent years, there has been a rapidly increasing number of studies focused on the relationship between dementia and metabolic disorders such as diabetes, obesity, hypertension and dyslipidemia. Etiological heterogeneity and co-morbidity pose challenges for determining relationships among metabolic disorders. The independent and interactive effects of brain vascular injury and classic pathological agents such as Aβ have also proved difficult to untangle in human patients, blurring the lines between Alzheimer's disease and vascular dementia. This review highlights recent work aimed at identifying convergent mechanisms such as insulin resistance that may underlie co-morbid metabolic disorders and thereby increase dementia risk. Identification of such convergent factors will not only provide important insights into the causes and interdependencies of late-life dementias, but will also inspire novel strategies for treating and preventing these disorders.Keywords
This publication has 42 references indexed in Scilit:
- Different Patterns of Cerebral Injury in Dementia With or Without DiabetesArchives of Neurology, 2009
- Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathologyNeurology, 2008
- Hypertension and Cerebrovascular DysfunctionCell Metabolism, 2008
- Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: An epidemiological perspectiveEuropean Journal of Pharmacology, 2008
- FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in miceJCI Insight, 2008
- Why a Cluster is Truly a Cluster: Insulin Resistance and Cardiovascular DiseaseClinical Chemistry, 2008
- Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer diseaseJCI Insight, 2008
- Clearance of amyloid-β by circulating lipoprotein receptorsNature Medicine, 2007
- Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer’s disease mouse models with abundant Aβ in plasmaNeurobiology of Disease, 2006
- Systemic Catabolism of Alzheimer's Aβ40 and Aβ42Online Journal of Public Health Informatics, 2004