Understanding the Role of Human Variation in Vaccine Adverse Events: The Clinical Immunization Safety Assessment Network
Open Access
- 1 May 2011
- journal article
- Published by American Academy of Pediatrics (AAP)
- Vol. 127 (Supplement), S65-S73
- https://doi.org/10.1542/peds.2010-1722j
Abstract
The Clinical Immunization Safety Assessment (CISA) Network is a collaboration between the Centers for Disease Control and Prevention (CDC) and 6 academic medical centers to provide support for immunization safety assessment and research. The CISA Network was established by the CDC in 2001 with 4 primary goals: (1) develop research protocols for clinical evaluation, diagnosis, and management of adverse events following immunization (AEFI); (2) improve the understanding of AEFI at the individual level, including determining possible genetic and other risk factors for predisposed people and subpopulations at high risk; (3) develop evidence-based algorithms for vaccination of people at risk of serious AEFI; and (4) serve as subject-matter experts for clinical vaccine-safety inquiries. CISA Network investigators bring in-depth clinical, pathophysiologic, and epidemiologic expertise to assessing causal relationships between vaccines and adverse events and to understanding the pathogenesis of AEFI. CISA Network researchers conduct expert reviews of clinically significant adverse events and determine the validity of the recorded diagnoses on the basis of clinical and laboratory criteria. They also conduct special studies to investigate the possible pathogenesis of adverse events, assess relationships between vaccines and adverse events, and maintain a centralized repository for clinical specimens. The CISA Network provides specific clinical guidance to both health care providers who administer vaccines and those who evaluate and treat patients with possible AEFI. The CISA Network plays an important role in providing critical immunization-safety data and expertise to inform vaccine policy-makers. The CISA Network serves as a unique resource for vaccine-safety monitoring efforts conducted at the CDC.Keywords
This publication has 28 references indexed in Scilit:
- Preterm Infants' T Cell Responses to Inactivated Poliovirus VaccineThe Journal of Infectious Diseases, 2010
- Recurrent sterile abscesses following aluminium adjuvant-containing vaccinesCase Reports, 2009
- Adverse event reports following yellow fever vaccinationVaccine, 2008
- An Algorithm for Treatment of Patients With Hypersensitivity Reactions After VaccinesPublished by American Academy of Pediatrics (AAP) ,2008
- SAFETY OF A FIFTH DOSE OF DIPHTHERIA AND TETANUS TOXOID AND ACELLULAR PERTUSSIS VACCINE IN CHILDREN EXPERIENCING EXTENSIVE, LOCAL REACTIONS TO THE FOURTH DOSEThe Pediatric Infectious Disease Journal, 2008
- Irritant skin test reactions to common vaccinesJournal of Allergy and Clinical Immunology, 2007
- A Role for Genetics in the Immune Response to the Varicella VaccineThe Pediatric Infectious Disease Journal, 2007
- Markers of Past Infection with Simian Virus 40 (SV40) and Risk of Incident Non-Hodgkin Lymphoma in a Maryland CohortCancer Epidemiology, Biomarkers & Prevention, 2005
- Anthrax vaccine and causality assessment from individual case reportsPharmacoepidemiology and Drug Safety, 2002
- Vaccine Safety Datalink Project: A New Tool for Improving Vaccine Safety Monitoring in the United StatesPediatrics, 1997