Bone regeneration: current concepts and future directions
Top Cited Papers
Open Access
- 31 May 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in BMC Medicine
- Vol. 9 (1), 66
- https://doi.org/10.1186/1741-7015-9-66
Abstract
Bone regeneration is a complex, well-orchestrated physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodelling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in large quantity, such as for skeletal reconstruction of large bone defects created by trauma, infection, tumour resection and skeletal abnormalities, or cases in which the regenerative process is compromised, including avascular necrosis, atrophic non-unions and osteoporosis. Currently, there is a plethora of different strategies to augment the impaired or 'insufficient' bone-regeneration process, including the 'gold standard' autologous bone graft, free fibula vascularised graft, allograft implantation, and use of growth factors, osteoconductive scaffolds, osteoprogenitor cells and distraction osteogenesis. Improved 'local' strategies in terms of tissue engineering and gene therapy, or even 'systemic' enhancement of bone repair, are under intense investigation, in an effort to overcome the limitations of the current methods, to produce bone-graft substitutes with biomechanical properties that are as identical to normal bone as possible, to accelerate the overall regeneration process, or even to address systemic conditions, such as skeletal disorders and osteoporosis.Keywords
This publication has 88 references indexed in Scilit:
- Improved healing response in delayed unions of the tibia with low-intensity pulsed ultrasound: results of a randomized sham-controlled trialBMC Musculoskeletal Disorders, 2010
- Clinical Application of Human Mesenchymal Stromal Cells for Bone Tissue EngineeringStem Cells International, 2010
- Efficacy of minimally invasive techniques for enhancement of fracture healing: evidence todayInternational Orthopaedics, 2009
- Is an Impacted Morselized Graft in a Cage an Alternative for Reconstructing Segmental Diaphyseal Defects?Clinical Orthopaedics and Related Research, 2009
- A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron™) injection to treat fracturesBMC Musculoskeletal Disorders, 2009
- Mesenchymal progenitor cells derived from traumatized human muscleJournal of Tissue Engineering and Regenerative Medicine, 2009
- European guidance for the diagnosis and management of osteoporosis in postmenopausal womenOsteoporosis International, 2008
- Therapeutic Potential of Vasculogenesis and Osteogenesis Promoted by Peripheral Blood CD34-Positive Cells for Functional Bone HealingThe American Journal of Pathology, 2006
- Parathyroid Hormone as an Anabolic Skeletal TherapyDrugs, 2005
- Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based TherapiesTissue Engineering, 2001