Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins
- 4 June 1999
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 284 (5420), 1664-1666
- https://doi.org/10.1126/science.284.5420.1664
Abstract
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs–4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373–alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.Keywords
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