Pyrimidine Nucleotide Synthesis: Regulatory Control during Transformation of Lymphocytes in vitro
- 1 June 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3779), 1237-1240
- https://doi.org/10.1126/science.156.3779.1237
Abstract
The incorporation of uridine into RNA in lymphocytes undergoing transformation induced by phytohemagglutinin parallels its incorporation into the intratcellular pool of acid-soluble nucleotides and coincides with a 20-fold increase in the specific activity of uridine kinase. This increase is dependent upon synthesis of both RNA and protein and is subject to both repression and end-product inhibition by cytidine.This publication has 10 references indexed in Scilit:
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