Homology between an endogenous viral LTR and sequences inserted in an activated cellular oncogene
Open Access
- 1 April 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 302 (5908), 547-548
- https://doi.org/10.1038/302547a0
Abstract
Recently, some of us reported1 the detection and molecular cloning of a rearranged cellular oncogene, designated rc-mos, from a non-virally-induced mouse myeloma, XRPC24. Recombinant λ phage DNA containing the rc-mos gene was active in transforming NIH 3T3 cells in a transfection assay, whereas recombinant DNA containing the unrearranged c-mos gene was not. In rc-mos, coding sequences from the 5′ end of c-mos were found to have been displaced by a novel cellular element whose nucleotide sequence was reported. We now document the fact that a 349-base pair (bp) segment of the novel DNA immediately adjacent to the retained c-mos sequences in rc-mos has close homology with the long terminal repeat (LTR) of a known intracisternal A-particle gene. This homology was mentioned in Nature recently2 after it had been brought to the attention of the editors (N. Hozumi and R. Hawley, personal communication).Keywords
This publication has 13 references indexed in Scilit:
- Rapid similarity searches of nucleic acid and protein data banks.Proceedings of the National Academy of Sciences, 1983
- Onco gen: What has moved into c-mos?Nature, 1983
- Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.Proceedings of the National Academy of Sciences of the United States of America, 1982
- Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like elementNature, 1982
- Form and Function of Retroviral ProvirusesScience, 1982
- Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosisNature, 1981
- Intracisternal A-particle genes in Mus musculus: a conserved family of retrovirus-like elements.Molecular and Cellular Biology, 1981
- Sequence organization of cloned intracisternal a particle genesCell, 1980
- Intracisternal A-particle genes: identification in the genome of Mus musculus and comparison of multiple isolates from a mouse gene library.Proceedings of the National Academy of Sciences, 1980
- Sequences associated with intracisternal a particles are reiterated in the mouse genomeCell, 1977