Molecular genetics of ameloblast cell lineage
- 17 December 2008
- journal article
- review article
- Published by Wiley in Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
- Vol. 312B (5), 437-444
- https://doi.org/10.1002/jez.b.21261
Abstract
Late tooth morphogenesis is characterized by a series of events that determine crown morphogenesis and the histodifferentiation of epithelial cells into enamel‐secreting ameloblasts and of mesenchymal cells into dentin‐secreting odontoblasts. Functional ameloblasts are tall, columnar, polarized cells that synthesize and secrete a number of enamel‐specific proteins. After depositing the full thickness of enamel matrix, ameloblasts shrink in size and regulate enamel maturation. Amelogenesis imperfecta (AI) is a heterogeneous group of inherited defects in enamel formation. Clinically, AI presents as a spectrum of enamel malformations that are categorized as hypoplastic, hypocalcified, or hypomaturation types, based upon the thickness and hardness of the enamel. The different types of AI are inherited, either as X‐linked, autosomal‐dominant, or autosomal‐recessive traits. Recently, several gene mutations have been identified to cause the subtypes of AI. How these genes, however, coordinate their function to control amelogenesis is not understood. In this review, we discuss the role of genes that play definitive role on the determination of ameloblast cell fate and life cycle based on studies in transgenic animals. J. Exp. Zool. (Mol. Dev. Evol.) 312B:437–444, 2009.Keywords
This publication has 67 references indexed in Scilit:
- Mutational spectrum ofFAM83H: the C-terminal portion is required for tooth enamel calcificationHuman Mutation, 2008
- Enamel Defects and Ameloblast-specific Expression in Enam Knock-out/lacZ Knock-in MicePublished by Elsevier BV ,2008
- FAM83H Mutations in Families with Autosomal-Dominant Hypocalcified Amelogenesis ImperfectaAmerican Journal of Human Genetics, 2008
- The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humansHuman Molecular Genetics, 2007
- An Integrated Gene Regulatory Network Controls Stem Cell Proliferation in TeethPLoS Biology, 2007
- Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epitheliumBiochemical Journal, 2006
- The molecular etiologies and associated phenotypes of amelogenesis imperfectaAmerican Journal of Medical Genetics Part A, 2006
- Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendagesDevelopment, 2004
- Expression and localization of laminin-5 subunits during mouse tooth developmentDevelopmental Dynamics, 1998
- Cloning of the Laminin α3 Chain Gene (LAMA3) and Identification of a Homozygous Deletion in a Patient with Herlitz Junctional Epidermolysis BullosaGenomics, 1995