Review: Veterinary Sources of Nonrodent Monoclonal Antibodies: Interspecific and Intraspecific Hybridomas
- 1 June 2000
- journal article
- review article
- Published by Mary Ann Liebert Inc in Hybridoma
- Vol. 19 (3), 201-214
- https://doi.org/10.1089/02724570050109602
Abstract
The generation of monoclonal antibodies from species other than rats and mice has developed slowly over the last 20 years. The advent of antibody engineering and realization of the advantages of nonmurine antibodies, in terms of their superior affinities and specificities, and their potential as components of human and veterinary therapeutics has increased their relevance recently. There have been significant advances in the development of myeloma and heteromyeloma fusion partners. This is an opportune moment to consolidate experiences of MAb production across the range of species of veterinary interest and place it into context with other developments in the field of monoclonal antibodies. The background to the development of antibodies from species other than the mouse is discussed. The species and antigens used to date are reviewed, as are the methods and results reported. A suggested protocol is provided for first attempts to exploit the huge potential of this aspect of hybridoma technology and suggestions are made for its further expansion.Keywords
This publication has 122 references indexed in Scilit:
- Production and Characterization of a Rabbit Monoclonal Antibody Against Human CDC25C PhosphataseHybridoma, 1998
- Monoclonal equine IgM and IgG immunoglobulinsVeterinary Immunology and Immunopathology, 1995
- A comparative study on the use of bovine and murine monoclonal antibodies for passive immunization in cattleVeterinary Immunology and Immunopathology, 1992
- The production of equine monoclonal immunoglobulins by horse-mouse heterohybridomasVeterinary Immunology and Immunopathology, 1992
- Bovine viral diarrhoea virus-specific bovine monoclonal antibodyArchiv für die gesamte Virusforschung, 1991
- A Bovine Monoclonal Antibody to Oestrone/Oestradiol Prepared by a (Murine×Bovine) ×Bovine Interspecies FusionVeterinary Immunology and Immunopathology, 1988
- The application of hybridoma technology to the study of bovine immunoglobulinsVeterinary Immunology and Immunopathology, 1987
- Bovine monoclonal antibodies to the F5 (K99) pilus antigen of E. coli, produced by murine/bovine hybridomasVeterinary Immunology and Immunopathology, 1987
- Porcine lymphoblastoid cell lines of B-cell originVeterinary Immunology and Immunopathology, 1985
- Production and characterization of monoclonal bovine immunoglobulins G1, G2 and M from bovine × murine hybridomasVeterinary Immunology and Immunopathology, 1984