The Furin Inhibitor Hexa-d-Arginine Blocks the Activation ofPseudomonas aeruginosaExotoxin A In Vivo
Open Access
- 1 December 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (12), 7136-7139
- https://doi.org/10.1128/iai.70.12.7136-7139.2002
Abstract
The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-d-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha.Keywords
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