The calcium‐sensing receptor and calcimimetics in blood pressure modulation
- 8 September 2011
- journal article
- review article
- Published by Wiley in British Journal of Pharmacology
- Vol. 164 (3), 884-893
- https://doi.org/10.1111/j.1476-5381.2011.01317.x
Abstract
Calcium is a crucial second messenger in the cardiovascular system. However, calcium may also be an extracellular first messenger through a G-protein-coupled receptor that senses extracellular concentration (Ca(2+)(o)), the calcium-sensing receptor (CaR). The most prominent physiological function of the CaR is to maintain the extracellular Ca(2+) level in a very tight range by regulating the circulating levels of parathyroid hormone (PTH). This control over PTH and Ca(2+) levels is partially lost in patients suffering from primary and secondary hyperparathyroidism. Allosteric modulators of the CaR (calcimimetics) are the first drugs in their class to become available for clinical use and have been shown to successfully treat certain forms of primary and secondary hyperparathyroidism. In addition, several studies suggest beneficial effects of calcimimetics on cardiovascular risk factors associated with hyperparathyroidism. Although a plethora of studies demonstrated the CaR in heart and blood vessels, exact roles of the receptor in the cardiovascular system still remain to be elucidated. However, several studies point toward a possibility that the CaR might be involved in the regulation of vascular tone. This review will summarize the current knowledge on the possible functions of the CaR and calcimimetics on blood pressure regulation.Keywords
This publication has 89 references indexed in Scilit:
- Vascular actions of calcimimetics: role of Ca2+‐sensing receptors versus Ca2+ influx through L‐type Ca2+ channelsBritish Journal of Pharmacology, 2011
- Acute activation of the calcium-sensing receptor inhibits plasma renin activity in vivoAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010
- Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cellsAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2009
- The Calcium-Sensing Receptor Promotes Urinary Acidification to Prevent NephrolithiasisJournal of the American Society of Nephrology, 2009
- Association of the Calcium-Sensing Receptor Gene with Blood Pressure and Urinary Calcium in African-AmericansJournal of Clinical Endocrinology & Metabolism, 2009
- The Extracellular Calcium-Sensing Receptor (CaSR) Is a Critical Modulator of Skeletal DevelopmentScience Signaling, 2008
- The expression and function of Ca2+‐sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetesBritish Journal of Pharmacology, 2008
- Modulation of Endothelial Cell K Ca 3.1 Channels During Endothelium-Derived Hyperpolarizing Factor Signaling in Mesenteric Resistance ArteriesCirculation Research, 2008
- Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptorNature Neuroscience, 2008
- Expression of a functional extracellular calcium-sensing receptor in human aortic endothelial cellsBiochemical and Biophysical Research Communications, 2006