Expression of SHP2 and Related Markers in Non–Small Cell Lung Cancer
- 1 October 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Applied Immunohistochemistry & Molecular Morphology
- Vol. 21 (5), 386-394
- https://doi.org/10.1097/pai.0b013e31827da3f9
Abstract
The purpose of this study was to assess the relationships between the expression of SHP2 and VEGF, VEGFR-1, VEGFR-2, MMP-2, MMP-9, TIMP-1, TIMP-2, and microvessel density (MVD), as well as the clinicopathologic parameters of these markers in non–small cell lung cancer (NSCLC). Using a tissue microarray, the expression of these 8 markers in 80 NSCLC cases was detected by immunohistochemistry. The expression of the markers was higher in cancer tissues when compared with the surrounding tissues. The MVD was lower in the CD34-positive cancer tissues than in the surrounding tissues. Significantly higher positive rates of expression for SHP2, MMP-9, and MMP-2 were observed in patients with lymph node metastases. The later the clinical stage was, the higher the expression of MMP-9 and MMP-2. The expression of VEGF in patients with lung squamous cell carcinomas was significantly higher than in patients with lung adenocarcinomas. The positive expression of SHP2 correlated significantly with that of VEGFR-2 and the MVD and a survival disadvantage was noted in the patients with SHP2-positive tumors. Therefore, our data suggest that the expression of SHP2 in NSCLC has high specificity and sensitivity and is closely related to lymph node metastasis and the expression of VEGFR-2 and the MVD in patients with NSCLC. SHP2 expression may promote the invasion and metastasis of NSCLC through angiogenesis and the lymphatic system.Keywords
This publication has 6 references indexed in Scilit:
- SHP2 Mediates the Localized Activation of Fyn Downstream of the α6β4 Integrin To Promote Carcinoma InvasionMolecular and Cellular Biology, 2010
- Increase in tissue inhibitor of metalloproteinase-2 (TIMP-2) levels and inhibition of MMP-2 activity in a metastatic breast cancer cell line by an anti-invasive small molecule SR13179Cancer Letters, 2010
- VEGF-targeted therapy: mechanisms of anti-tumour activityNature Reviews Cancer, 2008
- The tyrosine phosphatase Shp2 (PTPN11) in cancerCancer and Metastasis Reviews, 2008
- Angiogenesis in non-small cell lung cancerSeminars in Thoracic and Cardiovascular Surgery, 2004
- Matrix metalloproteinases in cancer invasion, metastasis and angiogenesisDrug Discovery Today, 2001