Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
Open Access
- 15 December 2000
- journal article
- research article
- Published by Springer Science and Business Media LLC in The EMBO Journal
- Vol. 19 (24), 6664-6674
- https://doi.org/10.1093/emboj/19.24.6664
Abstract
Growth and differentiation of postnatal hair follicles are controlled by reciprocal interactions between the dermal papilla and the surrounding epidermal hair precursors. The molecular nature of these interactions is largely unknown, but they are likely to involve several families of signaling molecules, including Fgfs, Wnts and Bmps. To analyze the function of Bmp signaling in postnatal hair development, we have generated transgenic mice expressing the Bmp inhibitor, Noggin, under the control of the proximal Msx2 promoter, which drives expression in proliferating hair matrix cells and differentiating hair precursor cells. Differentiation of the hair shaft but not the inner root sheath is severely impaired in Msx2–Noggin transgenic mice. In addition to hair keratins, the expression of several transcription factors implicated in hair development, including Foxn1 and Hoxc13 , is severely reduced in the transgenic hair follicles. Proliferating cells, which are normally restricted to the hair matrix surrounding the dermal papilla, are found in the precortex and hair shaft region. These results identify Bmps as key regulators of the genetic program controlling hair shaft differentiation in postnatal hair follicles.Keywords
This publication has 45 references indexed in Scilit:
- Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2Journal of Investigative Dermatology, 1999
- Sonic hedgehog signaling is essential for hair developmentCurrent Biology, 1998
- Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian SkeletonScience, 1998
- Basal Cell Carcinomas in Mice Overexpressing Sonic HedgehogScience, 1997
- New member of the winged-helix protein family disrupted in mouse and rat nude mutationsNature, 1994
- Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth developmentCell, 1993
- Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles.Genes & Development, 1993
- The secret life of the hair follicleTrends in Genetics, 1992
- Nude Mice Are Not HairlessCells Tissues Organs, 1990
- Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.The Journal of cell biology, 1986