Polyphyletic Emergence of Linezolid-Resistant Staphylococci in the United States
- 1 February 2010
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 54 (2), 742-748
- https://doi.org/10.1128/aac.00621-09
Abstract
Since the year 2000, linezolid has been used in the United States to treat infections caused by antimicrobial-resistant Gram-positive cocci. At present, linezolid-resistant (Lin r ) Staphylococcus aureus and Staphylococcus epidermidis strains are rare and the diversity of their genetic backgrounds is unknown. We performed sequence-based strain typing and resistance gene characterization of 46 Lin r isolates that were collected from local and national sources between the years 2004 and 2007. Resistance was found to occur in at least three clonal complexes (CCs; lineages) of S. aureus and in at least four subclusters of a predominant, phylogenetically unstable CC of S. epidermidis . New candidate resistance mutations in 23S rRNA and the L4 riboprotein were identified among the S. epidermidis isolates. These findings suggest that linezolid resistance has emerged independently in multiple clones of S. aureus and with a variety of ribosomal mutations in multiple clones of S. epidermidis .Keywords
This publication has 38 references indexed in Scilit:
- Linezolid-ResistantStaphylococcus cohnii,GreeceEmerging Infectious Diseases, 2009
- Delayed Development of Linezolid Resistance in Staphylococcus aureus following Exposure to Low Levels of Antimicrobial AgentsAntimicrobial Agents and Chemotherapy, 2008
- First Report of cfr -Mediated Resistance to Linezolid in Human Staphylococcal Clinical Isolates Recovered in the United StatesAntimicrobial Agents and Chemotherapy, 2008
- Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistantStaphylococcus aureusresistant to the synthetic antibiotic linezolidMolecular Microbiology, 2007
- Assessing the reliability of eBURST using simulated populations with known ancestryBMC Microbiology, 2007
- Inferring a Population Structure for Staphylococcus epidermidis from Multilocus Sequence Typing DataJournal of Bacteriology, 2007
- Use of Outer Surface Protein Repeat Regions for Improved Genotyping of Staphylococcus epidermidisJournal of Clinical Microbiology, 2007
- In Vitro Activity of the Oxazolidinone RWJ-416457 against Linezolid-Resistant and -Susceptible Staphylococci and EnterococciAntimicrobial Agents and Chemotherapy, 2007
- Improved Multilocus Sequence Typing Scheme for Staphylococcus epidermidisJournal of Clinical Microbiology, 2007
- Combination of Multiplex PCRs for Staphylococcal Cassette Chromosome mec Type Assignment: Rapid Identification System for mec , ccr , and MajorDifferences in Junkyard RegionsAntimicrobial Agents and Chemotherapy, 2007