Diabetes is a rapidly escalating health problem. Researchers have discovered novel strategies for the treatment of diabetes. Since ancient times, Sadabahar has been utilised to control diabetes in many regions of the world. Also known as Catharanthus roseus, it has been used in Ayurveda and Chinese medicine for centuries and is claimed to be a tried-and-true herbal remedy for chronic illnesses like diabetes. Over 120 alkaloids are produced, with 70 of them being pharmacologically active. Beneficial flavonoids and hypoglycemic alkaloids like catharanthine, leurosine, lochnerine, tetrahydroalstonin, vindoline, and vindolinine, vindogentianine are found in the plant. Researches have shown that the ethyl acetate fraction of the ethanolic extract of C. roseus has the best glucose lowering effect. This study focuses on the various biotechnological methods being adopted with constant advancements towards the role of sadabahar in treatment of diabetes and its future prospects.