The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus
Open Access
- 1 January 2013
- journal article
- research article
- Published by Hindawi Limited in International Journal of Endocrinology
- Vol. 2013, 1-7
- https://doi.org/10.1155/2013/842598
Abstract
To study the correlations between serum osteocalcin and glucose metabolism in patients with type 2 diabetes, 66 cases were collected to determine total osteocalcin, undercarboxylated osteocalcin, fasting blood glucose, fasting insulin, and HbA1c. Osteocalcin concentrations were compared between groups of different levels of HbA1c, and parameters of glucose metabolism were compared between groups of different levels of total osteocalcin and undercarboxylated osteocalcin. The relationship between osteocalcin and parameters of glucose metabolism was also analyzed. We found that the total osteocalcin concentration of high-HbA1c group was significantly lower than that of low-HbA1c group. The fasting blood glucose of low-total-osteocalcin group was significantly higher than that of high-total-osteocalcin group in male participants, while the fasting blood glucose of low-undercarboxylated-osteocalcin group was significantly higher than that of high-undercarboxylated-osteocalcin group in all participants and in male participants. Total osteocalcin was inversely correlated with HbA1c, and undercarboxylated osteocalcin was inversely correlated with fasting blood glucose. However, no significant correlation was found between osteocalcin and HOMA-IR. Total osteocalcin was an independent related factor of HbA1c level. In summary, decreased serum total osteocalcin and undercarboxylated osteocalcin are closely related to the exacerbation of glucose metabolism disorder but have no relations with insulin resistance.Keywords
Funding Information
- Zhejiang Province Science and Technology Project (2010C33029)
This publication has 17 references indexed in Scilit:
- Bone and glucose metabolism: A two-way streetArchives of Biochemistry and Biophysics, 2010
- Carboxylation of Osteocalcin Affects Its Association With Metabolic Parameters in Healthy ChildrenDiabetes Care, 2009
- Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individualsActa Endocrinologica, 2009
- γ-Carboxylation of osteocalcin and insulin resistance in older men and womenThe American Journal of Clinical Nutrition, 2009
- Effect of Vitamin K Supplementation on Insulin Resistance in Older Men and WomenDiabetes Care, 2008
- Relationship between osteocalcin and glucose metabolism in postmenopausal womenClinica Chimica Acta; International Journal of Clinical Chemistry, 2008
- Effect of Vitamin K Supplementation on Bone Loss in Elderly Men and WomenJournal of Clinical Endocrinology & Metabolism, 2008
- Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type miceProceedings of the National Academy of Sciences of the United States of America, 2008
- Endocrine Regulation of Energy Metabolism by the SkeletonCell, 2007
- Vitamin K Status and Bone Health: An Analysis of Methods for Determination of Undercarboxylated OsteocalcinJournal of Clinical Endocrinology & Metabolism, 1998