Antiviral Activity of Adenine Arabinoside and Iododeoxyuridine in Human Fetal Intestinal and Tracheal Organ Cultures

Abstract

Isolates of Escherichia coliand Salmonella speciesobtained from humans, animals, and their rural environments were tested for their ability to transfer multiple drug resistance to competent recipients. In all, 128 (52.9%) of 242 isolates of E. colitransferred all or part of their resistance to E. coli CSH-2, and 103 (44.4%) of 232 isolates of E. colitransferred all or part of their resistance to Salmonella choleraesuisvar. kuzendorf214. The data suggest that the multiple drug resistance of E. coliin the gut of humans who work with livestock may be due to the transfer of resistance determinants from animal strains to the resident flora of the human gut. Such transfer could occur during transient passage through the digestive tract. Multiple drug-resistant Salmonella were isolated from all sources. In all, 48 (80%) of 60 isolates of Salmonella transferred all or part of their resistance to E. coliCSH-2, and 42 (82.4%) of 51 isolates of Salmonellatransferred all or part of their resistance to S. choleraesuisvar. kuzendorf214. Fifty-three (46.9%) of 113 antibiotic-sensitive isolates of E. colipossessed resistance transfer factor, and six (23.1%) of 26 isolates with resistance transfer factor mobilized resistance determinants in isolates unable to transfer drug resistance during conjugation experiments.