Point of care platelet function testing in routine neurointerventional care is unjustified

Abstract

Meta-analyses have shown an increased rate of poor outcome (stent thrombosis, myocardial infarction, and death) in patients with high persistent platelet reactivity (non-response) treated for symptomatic coronary atherothrombosis.1 However, modification of antiplatelet therapy according to point of care platelet function testing did not reduce the rate of poor outcome (stent thrombosis, myocardial infarction, and death) in the recent ARCTIC (Assessment by a Double Randomization of a Conventional Antiplatelet Strategy versus a Monitoring-guided Strategy for Drug-Eluting Stent Implantation and of Treatment Interruption versus Continuation One Year after Stenting Trial)2 and GRAVITAS (Gauging Responsiveness with a VerifyNow assay—Impact on Thrombosis And Safety)3 trials.