Thinness at Birth and Glucose Tolerance in Seven‐year‐old Children
- 1 January 1995
- journal article
- Published by Wiley in Diabetic Medicine
- Vol. 12 (1), 24-29
- https://doi.org/10.1111/j.1464-5491.1995.tb02057.x
Abstract
Adults who had low birthweight and were thin at birth have an increased risk of Type 2 diabetes and impaired glucose tolerance. To discover whether thinness at birth is associated with reduced glucose tolerance in children, 250 7-year-old children underwent an abbreviated oral glucose tolerance test. Children who were thin at birth, as measured by a low ponderal index (birthweight length-3) had higher plasma glucose concentrations. Plasma glucose concentration 30 min after a glucose load rose by 0.07 mmol l-1 (95% confidence interval 0.00 to 0.14; p = 0.04) for every unit (kg m-3) fall in ponderal index. Children in the lowest quarter of the distribution of ponderal index (23 kg m-3 or less) had a mean 30 min plasma glucose concentration of 8.49 mmol l-1 compared to a mean of 7.97 mmol l-1 for those in the highest quarter (>27.5 kg m-3). These associations were independent of duration of gestation, gender, social class or the child's current weight. This is consistent with the hypothesis that Type 2 diabetes originates in utero.Keywords
This publication has 21 references indexed in Scilit:
- Birthweight and adult health outcomes in a biethnic population in the USADiabetologia, 1994
- Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype?BMJ, 1994
- Thinness at birth and insulin resistance in adult lifeDiabetologia, 1994
- Fetal growth and impaired glucose tolerance in men and womenDiabetologia, 1993
- Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growthDiabetologia, 1993
- The relation of fetal growth to plasma glucose in young menDiabetologia, 1992
- Maternal and fetal influences on blood pressure.Archives of Disease in Childhood, 1991
- Fetal and infant growth and impaired glucose tolerance at age 64.BMJ, 1991
- Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulinsBiochemical Journal, 1989
- Role of Insulin Resistance in Human DiseaseDiabetes, 1988