Suppression of plasma matrix metalloproteinase-9 following montelukast treatment in childhood asthma
- 1 December 2007
- journal article
- Published by Wiley in Pediatrics International
- Vol. 49 (6), 918-922
- https://doi.org/10.1111/j.1442-200x.2007.02497.x
Abstract
Montelukast and ketotifen are commonly prescribed anti-inflammatory medications used in the treatment of childhood asthma. To investigate the modulation effect of montelukast and ketotifen, the levels of exhaled nitric oxide (eNO) and plasma matrix metalloproteinase-9 (MMP-9) were analyzed in a group of 30 children with mild persistent asthma. Patients on montelukast therapy for 8 weeks had significantly decreased levels of eNO and plasma MMP-9, which were associated with improved symptoms and enhanced peak expiratory flow but not significantly associated with increased level of tissue inhibitor metalloproteinase-1 (TIMP-1). In contrast, treatment with ketotifen produced no significant changes in these parameters until 4-6 weeks into the therapy and no effect on plasma MMP-9. Leukotriene antagonists, such as montelukast, may be better non-steroidal anti-inflammatory drugs for preventing airway inflammation in mild childhood asthma.Keywords
This publication has 23 references indexed in Scilit:
- Steroid naive eosinophilic asthma: anti-inflammatory effects of fluticasone and montelukastThorax, 2005
- Increased circulating 92 kDa matrix metalloproteinase (MMP-9) activity in exacerbations of asthmaThorax, 2003
- Elevated Levels of Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloproteinase 1 during the Acute Phase of Kawasaki DiseaseClinical and Vaccine Immunology, 2003
- New functions for the matrix metalloproteinases in cancer progressionNature Reviews Cancer, 2002
- Ketotifen for asthma in children aged 5 to 15 years: a randomized placebo-controlled trialAnnals of Allergy, Asthma & Immunology, 2000
- Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.Thorax, 1998
- Increased Release of Matrix Metalloproteinase-9 in Bronchoalveolar Lavage Fluid and by Alveolar Macrophages of AsthmaticsAmerican Journal of Respiratory Cell and Molecular Biology, 1997
- The effect of ketotifen on nitric oxide synthase activityBritish Journal of Pharmacology, 1997
- A double-blind, placebo-controlled comparison of sodium cromoglycate and ketotifen in the treatment of childhood asthmaAllergy, 1995
- Prevention of asthma with ketotifen in preasthmatic children: a three‐year follow‐up studyClinical and Experimental Allergy, 1995