Synergistic Dimetallic Effects in Propargylic Substitution Reaction Catalyzed by Thiolate-Bridged Diruthenium Complex

Abstract

The origin of unique catalytic activity of a thiolate-bridged diruthenium complex in nucleophilic substitution reactions of propargylic alcohols, which features a diruthenium−allenylidene complex as a key intermediate, was studied with the aid of density functional calculations (B3LYP). Comparison of mono- and diruthenium systems has shown that the rigid but reasonably flexible Ru−Ru core structure plays a critical role in the catalyst turnover step (i.e., dissociative ligand exchange of the product π-complex with the starting propargyl alcohol that goes through a coordinatively unsaturated Ru complex). In the diruthenium system, the energy loss due to coordinative unsaturation can be compensated by reinforcement of the Ru−Ru bond, while such an effect is unavailable in the monoruthenium counterpart. Weaker back-donation ability of the diruthenium complex is also advantageous for dissociation of the π-complex. Thus, ligand exchange takes place smoothly in the diruthenium system to regenerate the reactive species, while the monoruthenium reaction stops at a dead-end Ru product π-complex. The present studies have also shown the important role of protic molecules (e.g., MeOH) that mediate smooth proton transfer in the propargyl alcohol−allenylidene transformation.