Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer
- 1 May 2015
- journal article
- review article
- Published by BMJ in International Journal of Gynecologic Cancer
- Vol. 25 (4), 566-569
- https://doi.org/10.1097/igc.0000000000000413
Abstract
Long noncoding RNAs (lncRNAs) are longer than 200-nucleotide, noncoding transcripts in length, have a variety of biological functions, and are closely associated with tumor development. Ovarian cancer, as 1 of the 3 common gynecological malignancies, is the leading cause of death in women with gynecological malignant tumor. In this study, a review of the literature found that lncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation. Hence, in this article, the progress of above-mentioned 3 kinds of lncRNAs in ovarian cancer was reviewed and designed to help in the diagnosis, treatment, and prognosis of ovarian cancer.Keywords
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