Thrombospondin‐4 regulates fibrosis and remodeling of the myocardium in response to pressure overload
Open Access
- 23 February 2012
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 26 (6), 2363-2373
- https://doi.org/10.1096/fj.11-190728
Abstract
Thrombospondin-4 (TSP-4) expression increases dramatically in hypertrophic and failing hearts in rodent models and in humans. The aim of this study was to address the function of TSP-4 in the heart. ...Keywords
Funding Information
- National Institutes of Health (P50 HL077107, R01 DK067532)
This publication has 42 references indexed in Scilit:
- Thrombospondin-4 Is Required for Stretch-Mediated Contractility Augmentation in Cardiac MuscleCirculation Research, 2011
- Thrombospondin-4 Regulates Vascular Inflammation and AtherogenesisCirculation Research, 2010
- Pressure Overload–Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic FunctionCirculation, 2009
- Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overloadHistochemistry and Cell Biology, 2008
- Thrombospondin-2 Modulates Extracellular Matrix Remodeling during Physiological AngiogenesisThe American Journal of Pathology, 2008
- Thrombospondin-4 expression is rapidly upregulated by cardiac overloadBiochemical and Biophysical Research Communications, 2008
- Vascular Endothelial Growth Factor Blockade Promotes the Transition From Compensatory Cardiac Hypertrophy to Failure in Response to Pressure OverloadHypertension, 2006
- Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null miceMatrix Biology, 2005
- Distinct Upregulation of Extracellular Matrix Genes in Transition From Hypertrophy to Hypertensive Heart FailureHypertension, 2005
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001