Integrated Electrophoresis Chips/Amperometric Detection with Sputtered Gold Working Electrodes
- 4 August 1999
- journal article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 71 (17), 3901-3904
- https://doi.org/10.1021/ac9904720
Abstract
An on-chip electrochemical detector for micromachined capillary electrophoresis (CE) systems, based on sputtering a gold working electrode directly onto the capillary outlet, is described. The new on-chip detector preparation requires no microfabrication or alignment procedures nor a decoupling mechanism. The attractive performance of the integrated electrophoresis chips/amperometric detection was demonstrated for the anodic detection of neurotransmitters. The response for dopamine was linear from 20 to 200 μM, with a LOD of 1.0 μM and a sensitivity of 52 pA/μM. Such intimate coupling of capillary electrophoresis chips and electrochemical detection facilitates the realization of complete integrated microanalytical devices.Keywords
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