All‐Dry Synthesis and Coating of Methacrylic Acid Copolymers for Controlled Release
- 10 April 2007
- journal article
- research article
- Published by Wiley in Macromolecular Bioscience
- Vol. 7 (4), 429-434
- https://doi.org/10.1002/mabi.200700017
Abstract
Initiated chemical vapor deposition (iCVD) is presented as an all-dry synthesis and coating method for applying methacrylic acid copolymers as pH-responsive controlled release layers. iCVD combines the strengths of liquid-phase chemical synthesis with a precision solvent-free chemical vapor deposition environment. Copolymers of methacrylic acid and ethyl acrylate were confirmed by a systematic shift in the carbonyl bond stretching mode with a shift in the comonomer ratio within the copolymer and by the ability to apply the Fineman–Ross copolymerization equation to describe copolymerization kinetics. Copolymers of methacrylic acid and ethylene dimethacrylate showed pH-dependent swelling behavior that was applied to the enteric release of fluorescein and ibuprofen.Keywords
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