Pneumatosis Intestinalis Predictive Evaluation Study (PIPES)
- 1 July 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Journal of Trauma and Acute Care Surgery
- Vol. 75 (1), 15-23
- https://doi.org/10.1097/ta.0b013e318298486e
Abstract
Pneumatosis intestinalis (PI) is associated with numerous adult conditions, ranging from benign to life threatening. To date, series of PI outcomes consist of case reports and small retrospective series. We conducted a retrospective multicenter study, involving eight centers, of PI from January 2001 to December 2010. Demographics, medical history, clinical presentation, and outcomes were collected. Primary outcome was the presence of pathologic PI defined as confirmed transmural ischemia at surgery or the withdrawal of clinical care and subsequent mortality. Forward logistic regression and a regression tree analysis was used to generate a clinical prediction rule for pathologic PI. During the 10-year study period, 500 patients with PI were identified. Of this number, 299 (60%) had benign disease, and 201 (40%) had pathologic PI. A wide variety of variables were statistically significant predictors of pathologic PI on univariate comparison. In the regression model, a lactate of 2.0 or greater was the strongest independent predictor of pathologic PI, with hypotension or vasopressor need, peritonitis, acute renal failure, active mechanical ventilation, and absent bowel sounds also demonstrating significance. Classification and regression tree analysis was used to create a clinical prediction rule. In this tree, the presence of a lactate value of 2.0 or greater and hypotension/vasopressor use had a predictive probability of 93.2%. Discerning the clinical significance of PI remains a challenge. We identified the independent predictors of pathologic PI in the largest population to date and developed of a basic predictive model for clinical use. Prospective validation is warranted. Epidemiologic study, level III.Keywords
This publication has 35 references indexed in Scilit:
- Pneumatosis coli as a rare complication of bowel preparationEndoscopy, 2010
- Simultaneous Pneumatosis Cystoides Intestinalis and Pneumomediastinum in a Patient with Systemic SclerosisThe Journal of Rheumatology, 2010
- Management of hepatic portal venous gas and pneumatosis intestinalis in critically sick adult patientsScandinavian Journal of Gastroenterology, 2009
- Pneumatosis Intestinalis and Hepatico-Portal-Mesenteric-Splenic Venous GasDigestive Surgery, 2008
- Pneumatosis Intestinalis in the Adult: Benign to Life-Threatening CausesAmerican Journal of Roentgenology, 2007
- Additive contribution of multiple factors in the development of pneumatosis intestinalis: a case report and review of the literatureClinical Rheumatology, 2006
- Thrombosis of the Portal Venous System after Splenectomy for TraumaThe Journal of Trauma and Acute Care Surgery, 2003
- Acute pneumatosis cystoides intestinalis following allogeneic transplantation – the surgeon's dilemmaBone Marrow Transplantation, 2002
- Gastric Pneumatosis and Hepatoportal Venous Gas in Blunt Trauma: Clinical Significance in a Case ReportThe Journal of Trauma and Acute Care Surgery, 2000
- Traumatic Pneumatosis Cystoides Intestinalis with Portal Venous Air EmbolismThe Journal of Trauma and Acute Care Surgery, 1997