Colorectal polyps in childhood
- 1 October 2012
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Pediatrics
- Vol. 24 (5), 632-637
- https://doi.org/10.1097/mop.0b013e328357419f
Abstract
Colorectal polyps are a common cause of gastrointestinal bleeding in children. This review updates the information on colorectal polyps and summarizes the recent advances in genetics, diagnosis, and treatment of polyps in the large intestine. A review of recent literature regarding colorectal polyps demonstrates an estimated detected prevalence of 6.1% overall and 12.0% among those with lower gastrointestinal bleeding during pediatric colonoscopy. Non-Caucasian races (e.g., black and Hispanic) are at higher risk for colorectal polyps in childhood. Recent data show juvenile polyps may recur in approximately 45% of children with multiple polyps and 17% of children with solitary polyps. A clinical trial showed that celecoxib, a cyclooxygenase (COX)-2 inhibitor, significantly reduced the number of colorectal polyps in children with familial adenomatous polyposis (FAP). Ethical challenges related to genetic tests for FAP have been newly examined. The utility of novel endoscopic techniques (e.g., enteroscopy) in Peutz-Jeghers Syndrome to prevent intussusception have been newly described. Although colorectal polyps in children are generally benign and easily removed, careful clinical evaluation and ongoing research are needed to identify the small proportion of children at risk for cancer. The current paradigm of using the polyp number at presentation as a primary determinant of subsequent surveillance may be inadequate for many patients.Keywords
This publication has 34 references indexed in Scilit:
- Prevalence of colorectal polyps in pediatric colonoscopy.Digestive Diseases and Sciences, 2011
- Juvenile Polyps and Juvenile Polyp Syndromes in ChildrenClinical Pediatrics, 2011
- Juvenile polyposis syndromeWorld Journal of Gastroenterology, 2011
- Juvenile Polyps: Recurrence in Patients With Multiple and Solitary PolypsClinical Gastroenterology and Hepatology, 2010
- Gastrointestinal Polyps in ChildrenPediatrics & Neonatology, 2009
- Clinical and Endoscopic Data in Juvenile Polyposis Syndrome in Preadolescent ChildrenJournal of Clinical Gastroenterology, 2009
- Matrix Metalloproteinases in the Urine and Tissue of Patients With Juvenile Polyps: Potential Biomarkers for the Presence of PolypsJournal of Pediatric Gastroenterology and Nutrition, 2009
- Colonic Polyps in Children and AdolescentsCanadian Journal of Gastroenterology, 2007
- Solitary juvenile polyps: Not a marker for subsequent malignancyGastroenterology, 1993
- Colorectal neoplasia in juvenile polyposis or juvenile polyps.Archives of Disease in Childhood, 1991