Clinical study of fk506 in patients with myasthenia gravis
- 16 October 2003
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 28 (5), 570-574
- https://doi.org/10.1002/mus.10472
Abstract
To investigate the usefulness of low‐dose FK506 for the treatment of myasthenia gravis (MG), we treated 19 patients with generalized MG in a 16‐week open clinical trial of FK506 (3–5 mg/day). At the end of the trial, total MG scores (range: 0–27 points) improved by 3 points or more in 7 of 19 patients (37%), and activities of daily living (ADL) scores (range: 0–6 points) also improved by 1 point or more in 8 of 19 patients (42%). Nine of 19 patients (47%) showed improvement in either MG or ADL scores. Significant reduction of anti‐acetylcholine receptor antibody titers and interleukin 2 production were observed at the end of this study. Minor but commonly observed side effects were an increase in neutrophil count and a decrease in lymphocyte count. No serious adverse events such as renal toxicity or diabetes mellitus were observed during the 16‐week treatment period. FK506 could safely serve as an adjunct to steroid therapy for MG at low dosage. Muscle Nerve 28: 570–574 2003This publication has 12 references indexed in Scilit:
- FK506 Prevents Induction of Rat Experimental Autoimmune Myasthenia GravisJournal of Autoimmunity, 1997
- Myasthenia GravisThe New England Journal of Medicine, 1994
- A Clinical Therapeutic Trial of Cyclosporine in Myasthenia GravisaAnnals of the New York Academy of Sciences, 1993
- The mechanism of action of cyclosporin A and FK506Immunology Today, 1992
- A Simple Radioimmunoassay of Human Interleukin-2Journal of Immunoassay, 1988
- FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.The Journal of Antibiotics, 1987
- Effects of Preoperative Duration of Symptoms on Patients with Myasthenia GravisThe Annals of Thoracic Surgery, 1984
- Long‐term corticosteriod treatment of myasthenia gravis: Report of 116 PatientsAnnals of Neurology, 1984
- Myasthenia gravisNeurology, 1983
- Antibody to acetylcholine receptor in myasthenia gravisNeurology, 1976