Perinucleolar compartment and transformation
- 15 March 2005
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 95 (2), 217-225
- https://doi.org/10.1002/jcb.20403
Abstract
The perinucleolar compartment (PNC) is a sub‐nuclear structure that preferentially localizes to the nucleolar periphery. The PNC is found predominantly in transformed cells both in vitro and in vivo. PNC prevalence (the percentage of cells containing at least one PNC) positively correlates with the progression of breast cancer and patient survival. PNCs are highly enriched with newly synthesized RNA polymerase III transcripts and RNA‐binding proteins. The structural integrity of the PNC is dependent upon the transcription of these RNAs and a critical level of the polypyrimidine tract binding (PTB) protein, as assayed by the localization of other PNC‐associated proteins. These observations suggest a model in which the PNC is a dynamic, functional organelle that forms under specific physiological conditions favoring cellular transformation and might be involved in the metabolism of RNA polymerase III transcripts.Keywords
This publication has 48 references indexed in Scilit:
- The PTB interacting protein raver1 regulates -tropomyosin alternative splicingThe EMBO Journal, 2003
- Nuclear speckles: a model for nuclear organellesNature Reviews Molecular Cell Biology, 2003
- RNA Polymerase III Transcripts and the PTB Protein Are Essential for the Integrity of the Perinucleolar CompartmentMolecular Biology of the Cell, 2003
- Nucleolin Associates with a Subset of the Human Ro Ribonucleoprotein ComplexesJournal of Molecular Biology, 2002
- Eukaryotic Ribonuclease P: A Plurality of Ribonucleoprotein EnzymesAnnual Review of Biochemistry, 2002
- Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteinsThe Journal of cell biology, 2001
- Review: Perinucleolar StructuresJournal of Structural Biology, 2000
- Architecture and Function of the Human Endonucleases RNase P and RNase MRPIUBMB Life, 2000
- An intron enhancer recognized by splicing factors activates polyadenylation.Genes & Development, 1996
- A perinucleolar compartment contains several RNA polymerase III transcripts as well as the polypyrimidine tract-binding protein, hnRNP I [published erratum appears in J Cell Biol 1995 Jul;130(2):497-500]The Journal of cell biology, 1995