Vascularization of the Dorsal Root Ganglia and Peripheral Nerve of the Mouse: Implications for Chemical-Induced Peripheral Sensory Neuropathies
Open Access
- 1 January 2008
- journal article
- Published by SAGE Publications in Molecular Pain
- Vol. 4, 10
- https://doi.org/10.1186/1744-8069-4-10
Abstract
Although a variety of industrial chemicals, as well as several chemotherapeutic agents used to treat cancer or HIV, preferentially induce a peripheral sensory neuropathy what remains unclear is why these agents induce a sensory vs. a motor or mixed neuropathy. Previous studies have shown that the endothelial cells that vascularize the dorsal root ganglion (DRG), which houses the primary afferent sensory neurons, are unique in that they have large fenestrations and are permeable to a variety of low and high molecular weight agents. In the present report we used whole-mount preparations, immunohistochemistry, and confocal laser scanning microscopy to show that the cell body-rich area of the L4 mouse DRG has a 7 fold higher density of CD31+ capillaries than cell fiber rich area of the DRG or the distal or proximal aspect of the sciatic nerve. This dense vascularization, coupled with the high permeability of these capillaries, may synergistically contribute, and in part explain, why many potentially neurotoxic agents preferentially accumulate and injure cells within the DRG. Currently, cancer survivors and HIV patients constitute the largest and most rapidly expanding groups that have chemically induced peripheral sensory neuropathy. Understanding the unique aspects of the vascularization of the DRG and closing the endothelial fenestrations of the rich vascular bed of capillaries that vascularize the DRG before intravenous administration of anti-neoplastic or anti-HIV therapies, may offer a mechanism based approach to attenuate these chemically induced peripheral neuropathies in these patients.Keywords
This publication has 59 references indexed in Scilit:
- An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the ratBrain Research, 2007
- NeuroprotectionArchives of Neurology, 2007
- Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: Protease inhibitor–mediated neurotoxicityAnnals of Neurology, 2006
- Distribution of lymphatic vessels in mouse thymus: immunofluorescence analysisCell and tissue research, 2006
- Peripheral neuropathy: A persisting challenge in paclitaxel-based regimesEuropean Journal of Cancer, 2006
- High-dose intensity oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX 7)European Journal of Cancer, 2001
- Experimental Neuropathy Induced by Methyl Mercury Compounds: Autoradiographic Study of GABA Uptake by Dorsal Root GangliaEuropean Neurology, 1986
- Vascular permeability and neurotoxicity.Environmental Health Perspectives, 1978
- Long-term toxicity study of methylmercuric chloride in monkeys (First report)Toxicology, 1973
- Peripheral Neuropathy Caused by Chemical AgentsCRC Critical Reviews in Toxicology, 1973