Bioactive glass nanofiber–collagen nanocomposite as a novel bone regeneration matrix
- 18 July 2006
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 79A (3), 698-705
- https://doi.org/10.1002/jbm.a.30848
Abstract
Nanoscale organized organic–inorganic nanocomposite systems have great potential in the development of biomaterials with advanced properties. Herein, we developed a novel nanocomposite biomaterial consisting of bioactive glass nanofiber (BGNF) and collagen reconstituted fibrous matrix for bone regenerative medicine. A sol–gel derived glass with a bioactive composition (58SiO2· 38CaO·4P2O5) was electrospun to a nanoscale fiber with an average diameter of ∼320 nm. The BGNF was subsequently hybridized with type I collagen, which is the main organic constituent of bone matrix. The BGNF and self-assembled collagen sol were combined in aqueous solution, and then crosslinked to produce a BGNF-collagen nanocomposite, in the form of either a thin membrane or a macroporous scaffold, by adopting appropriate processing conditions. The BGNF was observed to be distributed uniformly within the collagen reconstituted nanofibrous matrix. The nanocomposite matrices induced rapid formation of bone-like apatite minerals on their surfaces when incubated in a simulated body fluid, exhibiting excellent bioactivity in vitro. Osteoblastic cells showed favorable growth on the BGNF-collagen nanocomposite. In particular, the alkaline phosphatase activity of the cells on the nanocomposite was significantly higher than that on the collagen. This novel BGNF-collagen nanocomposite is believed to have significant potential in bone regeneration and tissue engineering applications. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006Keywords
This publication has 20 references indexed in Scilit:
- Fibrillar assembly and stability of collagen coating on titanium for improved osteoblast responsesJournal of Biomedical Materials Research Part A, 2005
- Biological and Medical Significance of Calcium PhosphatesAngewandte Chemie, 2002
- Bioactivity of three CaO–P2O5–SiO2 sol‐gel glassesJournal of Biomedical Materials Research, 2002
- Bioactive sol‐gel foams for tissue repairJournal of Biomedical Materials Research, 2001
- Bioactivity of sol-gel bioactive glass coated alumina implantsJournal of Biomedical Materials Research, 2000
- Processing and properties of sol-gel bioactive glassesJournal of Biomedical Materials Research, 2000
- Sol–gel derived carrier for the controlled release of proteinsBiomaterials, 1999
- BioceramicsJournal of the American Ceramic Society, 1998
- BIOACTIVE GLASSES: CLINICAL APPLICATIONSPublished by World Scientific Pub Co Pte Ltd ,1993
- Collagen as a BiomaterialAnnual Review of Biophysics and Bioengineering, 1974