Synthesis of 6-Acyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylic acids and their methyl esters
- 1 September 2007
- journal article
- research article
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 43 (9), 1382-1386
- https://doi.org/10.1134/s1070428007090205
Abstract
6-Acyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylic acids and methyl 6-acyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylates were synthesized by fusion of 4-aryl-2,4-dioxobutanoic acids and their methyl esters, respectively, with 1H-tetrazol-5-amine and aromatic aldehydes. The reaction of methyl 2,4-dioxopentanoate with 1H-tetrazol-5-amine and 2-fluorobenzaldehyde in boiling acetic acid gave methyl 6-acetyl-5-hydroxy-7-(2-fluorophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine-5-carboxylate.Keywords
This publication has 1 reference indexed in Scilit:
- Synthesis of Methyl 6-Acyl-7-aryl-4,7-dihydrotetrazolo-[1,5-a]pyrimidine-5-carboxylatesRussian Journal of Organic Chemistry, 2003