Representation of Future and Previous Spatial Goals by Separate Neural Populations in Prefrontal Cortex

Abstract

The primate prefrontal cortex plays a central role in choosing goals, along with a wide variety of additional functions, including short-term memory. In the present study, we examined neuronal activity in the prefrontal cortex as monkeys used abstract response strategies to select one of three spatial goals, a selection that depended on their memory of the most recent previous goal. During each trial, the monkeys selected a future goal on the basis of events from the previous trial, including both the symbolic visual cue that had appeared on that trial and the previous goal that the monkeys had selected. When a symbolic visual cue repeated from the previous trial, the monkeys stayed with their previous goal as the next (future) goal; when the cue changed, the monkeys shifted from their previous goal to one of the two remaining locations as their future goal. We found that prefrontal neurons had activity that reflected either previous goals or future goals, but only rarely did individual cells reflect both. This finding suggests that essentially separate neural networks encode these two aspects of spatial information processing. A failure to distinguish previous and future goals could lead to two kinds of maladaptive behavior. First, wrongly representing an accomplished goal as still pending could cause perseveration or compulsive checking, two disorders commonly attributed to dysfunction of the prefrontal cortex. Second, mistaking a pending goal as already accomplished could cause the failures of omission that occur commonly in dementia.