Cerebrovascular Effects of Central Depressants: A Study of Nitrous Oxide, Halothane, Pentobarbital and Ethanol during Normocapnia and Hypercapnia in the Rat
- 13 March 2009
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 45 (4), 287-295
- https://doi.org/10.1111/j.1600-0773.1979.tb02395.x
Abstract
The effect of the central depressants N2O, halothane, pentobarbital and ethanol on cerebral blood flow (CBF), cerebral O2 consumption (CMRO2) and cerebral vascular reactivity to CO2 were measured using the rapid and repetitive intra-arterial 133Xe injection technique modified for rat studies. The cerebrovascular resistance (CVR) during normocapnia in the pentobarbital group was significantly higher (P < 0.01) than in the N2O group indicating a vasoconstrictor effect of pentobarbital that may be clinically important, as the ability of barbiturates to contract vessels in healthy brain regions may partly explain the protective properties of the drugs against cerebral ischemia. Pentobarbital and ethanol may act synergistically with CO2 in depressing CMRO2 and cerebral vascular reactivity. Apparently N2O anesthesia (70% N2O: 30% O2) is suitable as a reference situation in rat studies of the effect of pharmocological agents on CBF, CMRO2 and cerebrovascular reactivity.Keywords
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