Adipocyte conversion of cultured 3T3-Ll preadipocytes by bezafibrate
- 9 March 1987
- journal article
- Published by Elsevier BV in Life Sciences
- Vol. 40 (10), 935-941
- https://doi.org/10.1016/0024-3205(87)90312-2
Abstract
Transient exposure of cultured 3T3-Ll preadipocytes to hypolipidemic fibrate drugs results in extensive adipocyte conversion. Adipocyte conversion in culture was characterized by an increase in neutral lipids content and in adipocyte marker enzymes like hormone-sensitive lipase and glycerol-3-phosphate dehydrogenase. Adipocyte conversion in culture was also accompanied by induction of cyanide-insensitive peroxisomal palmitoyl-CoA oxidation. The conversion pattern exerted by fibrate drugs in 3T3-Ll cells was similar to that reported previously for primary cultured epididymal preadipocytes (R. Brandes, R. Arad and J. Bar-Tana, Biochim. Biophys. Acta, , 314–321 (1986)), and seems to refute clonal selection in the conversion sequel initiated by fibrate drugs in primary cultured preadipocytes.
Keywords
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