Phase I Trial with BMS-275183, a Novel Oral Taxane with Promising Antitumor Activity
Open Access
- 15 March 2006
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 12 (6), 1760-1767
- https://doi.org/10.1158/1078-0432.ccr-05-2093
Abstract
Purpose: BMS-275183 is an orally administered C-4 methyl carbonate analogue of paclitaxel. We did a dose-escalating phase I study to investigate its safety, tolerability, pharmacokinetics, and possible antitumor activity.Keywords
This publication has 26 references indexed in Scilit:
- Randomized Pharmacokinetic and Pharmacodynamic Study of Docetaxel: Dosing Based on Body-Surface Area Compared With Individualized Dosing Based on Cytochrome P450 Activity Estimated Using a Urinary Metabolite of Exogenous CortisolJournal of Clinical Oncology, 2005
- Role of Cytochrome P450 Phenotyping in Cancer TreatmentJournal of Clinical Oncology, 2005
- Prediction of Irinotecan Pharmacokinetics by Use of Cytochrome P450 3A4 Phenotyping ProbesJNCI Journal of the National Cancer Institute, 2004
- Neurophysiological Study of Peripheral Neuropathy after High-Dose PaclitaxelClinical Cancer Research, 2004
- Limited Access Trial Using Amifostine for Protection Against Cisplatin- and Three-Hour Paclitaxel–Induced Neurotoxicity: A Phase II Study of the Gynecologic Oncology GroupJournal of Clinical Oncology, 2003
- Explaining Interindividual Variability of Docetaxel Pharmacokinetics and Pharmacodynamics in Asians Through Phenotyping and Genotyping StrategiesJournal of Clinical Oncology, 2002
- A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin ACancer Chemotherapy and Pharmacology, 2001
- Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestineProceedings of the National Academy of Sciences of the United States of America, 1997
- Paclitaxel (Taxol)New England Journal of Medicine, 1995
- THE USE OF CONFIDENCE OR FIDUCIAL LIMITS ILLUSTRATED IN THE CASE OF THE BINOMIALBiometrika, 1934