Exploration of Novel Anti-Oxidant Protein Sestrin in Frailty Syndrome in Elderly
Open Access
- 1 January 2018
- journal article
- research article
- Published by Aging and Disease in Aging and disease
- Vol. 9 (2), 220-227
- https://doi.org/10.14336/ad.2017.0423
Abstract
Frailty in elderly is very much familiar with a decline in the musculoskeletal system. Muscle degeneration in the lower organism was observed due to loss of anti-oxidant protein Sestrin. The aim of the study is to determine the level of Sestrin1 and Sestrin2 in the serum of frail and non-frail elderly to associate their impact in frailty syndrome. Subjects with age >= 65 years were enrolled from Geriatric Medicine OPD of All India Institute of Medical Sciences, New Delhi (N=92). Among them, 51 subjects were identified as frail and rest 41 were regarded as non-frail according to "deficit accumulation model of Rockwood." The study was performed by surface plasmon resonance and validated by western blot. Sestrin1 and Sestrin2 were found to be significantly reduced in frail compare to non-frail elderly. Furthermore, even after the adjustment for age, gender and education, the level of Sestrin1 and Sestrin2 remain significantly lower across the groups. The Sestrin1 level was significantly lower in various categories like age, gender, BMI, education, ADL, number of co-morbidity along with other clinico-pathological features. ROC analysis also revealed the distinction of frail and non-frail in respect to serum Sestrin1 and Sestrin2. This study highlighted the new and promising role of serum Sestrin in frail and non-frail elderly. In future, it can be utilized as molecular marker to assess the potential diagnostic value for clinical purpose.Keywords
This publication has 28 references indexed in Scilit:
- Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old HumansCell Metabolism, 2017
- Effects of physical exercise interventions in frail older adults: a systematic review of randomized controlled trialsBMC Geriatrics, 2015
- Biomarkers for physical frailty and sarcopenia: state of the science and future developmentsJournal of Cachexia, Sarcopenia and Muscle, 2015
- Frailty in the clinical scenarioThe Lancet, 2015
- PHARMACOLOGICAL INTERVENTIONS IN FRAILTY AND SARCOPENIA: REPORT BY THE INTERNATIONAL CONFERENCE ON FRAILTY AND SARCOPENIA RESEARCH TASK FORCEThe Journal of Frailty & Aging, 2015
- Peroxiredoxins and sports: new insights on the antioxidative defenseThe Journal of Physiological Sciences, 2012
- The Effect of Resistance Exercise on p53, Caspase-9, and Caspase-3 in Trained and Untrained MenJournal of Strength and Conditioning Research, 2012
- Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related PathologiesScience, 2010
- Untangling the Concepts of Disability, Frailty, and Comorbidity: Implications for Improved Targeting and CareThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2004
- Free radicals and tissue damage produced by exerciseBiochemical and Biophysical Research Communications, 1982