Post-transplant lymphoproliferative disorders with naso- and oropharyngeal manifestation
- 30 July 2015
- journal article
- research article
- Published by Frontiers Media SA in Transplant International
- Vol. 28 (11), 1299-1307
- https://doi.org/10.1111/tri.12632
Abstract
The nasopharyngeal/oropharyngeal lymphatic tissues represent the anatomical site of Epstein-Barr virus (EBV) entry. Post-transplant lymphoproliferative disorders (PTLD) are often associated with EBV, but little is known about the characteristics of nasopharyngeal/oropharyngeal mass-forming PTLD. Retrospective evaluation of our own PTLD database (n = 79) and the PubMed(®) database (n = 61) has been performed. Sinonasal/oro-/nasopharyngeal lymphatic masses were early lesions (n = 54/140, 38.5%), polymorphic PTLD (n = 32/140, 23%), monomorphic B-PTLD (n = 47/140, 33.5%) and T-PTLD (n = 7/140, 5%). One-fourth of lesions manifested as masses in the Waldeyer's ring, and in two-thirds of cases, swelling of tonsils was related to manifestation of benign early lesions. Tonsil infiltration by polymorphic PTLD and monomorphic PTLD was present in one-third of cases. Extratonsillar masses were mainly monomorphic PTLD. Meta-analysis of our data in combination with previously published data revealed that lung transplantation and young patients are at a higher risk for earlier manifestation of monomorphic PTLD. Therapy is similar to PTLD therapy strategies, in general reduced immunosuppression and chemotherapy for polymorphic and monomorphic PTLD, and diagnostic and therapeutic surgical gross tumour resection of tonsillar/adenoid lesions. In summary, it is relevant for the clinical differential diagnosis that oro-/nasopharyngeal aggressive PTLD manifested in ~30% as tonsillar masses and >90% at extratonsillar sites.Keywords
This publication has 59 references indexed in Scilit:
- Malignant lymphoma of the head and neckOral Diseases, 2010
- EBV-Associated Polymorphic Posttransplant Lymphoproliferative Disorder Presenting as Gingival UlcersInternational Journal of Surgical Pathology, 2009
- Molecular and Immunologic Mechanisms of Cancer Pathogenesis in Solid Organ Transplant RecipientsAmerican Journal of Transplantation, 2008
- Monomorphic post-transplant lymphoproliferative disorder of the tongue: case report and review of literatureDiagnostic Pathology, 2007
- Monomorphic Epstein-Barr virus (EBV)-associated large B-cell posttransplant lymphoproliferative disorder presenting as a tongue ulcer in a pancreatic transplant patientOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2006
- Sinonasal Posttransplant Lymphoproliferative Disorder in Pediatric Lung Transplant PatientsOtolaryngology -- Head and Neck Surgery, 2005
- Post-transplant lymphoproliferative disorders presenting as gingival overgrowth in patients immunosuppressed with ciclosporin. A report of two casesJournal of Clinical Periodontology, 2004
- Epstein–Barr virus‐related post‐transplant lymphoproliferative disease in solid organ transplant recipients, 1988–97: A Canadian multi‐centre experiencePediatric Transplantation, 2001
- Detection of Epstein-Barr Virus in Posttransplantation T Cell Lymphoma in a Kidney Transplant Recipient: Case Report and ReviewClinical Infectious Diseases, 2000
- Primary, multi-focal, non-Hodgkin's lymphoma of the jaws presenting as periodontal disease in a renal transplant patientInternational Journal of Oral & Maxillofacial Surgery, 1991