Memory B Cells without Somatic Hypermutation Are Generated from Bcl6-Deficient B Cells
Open Access
- 1 September 2002
- journal article
- research article
- Published by Elsevier BV in Immunity
- Vol. 17 (3), 329-339
- https://doi.org/10.1016/s1074-7613(02)00387-4
Abstract
After immunization with T cell-dependent antigens, the high-affinity B cells selected in germinal centers differentiate into memory B cells or long-lived antibody-forming cells. However, a role for germinal centers in development of these B lineage cells is still controversial. We show here that Bcl6-deficient B cells, which cannot develop germinal centers, differentiated into IgM and IgG1 memory B cells in the spleen but barely differentiated into long-lived IgG1 antibody-forming cells in the bone marrow. Mutation in the V-heavy gene was null in these memory B cells. Therefore, Bcl6 and germinal center formation are essential for somatic hypermutation, and generation of memory B cells can occur independently of germinal center formation, somatic hypermutation, and Ig class switching.Keywords
This publication has 62 references indexed in Scilit:
- Antigen-Specific B Cell MemoryThe Journal of Experimental Medicine, 2000
- CXCR5-deficient mice develop functional germinal centers in the splenic T cell zoneEuropean Journal of Immunology, 2000
- Immunological tolerance in germinal centresImmunology Today, 1997
- Multiple Domains Participate in Distance-Independent LAZ3/BCL6-Mediated Transcriptional RepressionBiochemical and Biophysical Research Communications, 1996
- Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent AntigenImmunity, 1996
- Life and Death in Germinal Centers (Redux)Immunity, 1996
- RAG-1-deficient mice have no mature B and T lymphocytesCell, 1992
- Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigensEuropean Journal of Immunology, 1991
- Maturation of the immune response in germinal centersCell, 1991
- Maintenance of B-cell memory by long-lived cells generated from proliferating precursorsNature, 1990