Optical coherence tomography and neurodegeneration: are eyes the windows to the brain?
- 9 May 2016
- journal article
- review article
- Published by Taylor & Francis Ltd in Expert Review of Neurotherapeutics
- Vol. 16 (7), 765-775
- https://doi.org/10.1080/14737175.2016.1180978
Abstract
Introduction: Central nervous system (CNS) pathologies have ocular manifestations due to direct and/or retrograde degeneration of the visual pathways, most often related to a direct injury to the optic nerve, retinal ganglion cells and/or its surrounding cells. These ocular manifestations can be recognized and monitored by a non-invasive technique called Optical Coherence Tomography (OCT). Areas Covered: This review article describes the OCT technique and its application in various neurological pathologies. OCT helps in the measurement of retinal nerve fiber layer thickness (RNFLT) and macular thickness which consists of retinal ganglion cells. OCT provides a near-histological level of image resolution up to 5µm by using principles of interferometry that can detect CNS inflammatory, as well as degenerative, pathologies (i.e Multiple Sclerosis, Parkinson’s disease and Alzheimer’s Disease etc.) at initial clinical and possibly subclinical stages. Expert Commentary: RNFLT and macular volumes measured by OCT can serve as biomarkers for early recognition and progression of a variety of neurological disease, although the specificity of these findings in clinical diagnosis requires further refinement. An early biomarker can help in an earlier therapeutic intervention and thus preventing further progression and provide the opportunity for possible regenerative interventions of the underlying disease process. With the advent of “next-generation” OCT technology an increase in use is foreseen in research as well as in clinical practice.Keywords
This publication has 77 references indexed in Scilit:
- Multiparametric, Longitudinal Optical Coherence Tomography Imaging Reveals Acute Injury and Chronic Recovery in Experimental Ischemic StrokePLOS ONE, 2013
- Anterograde Degeneration along the Visual Pathway after Optic Nerve InjuryPLOS ONE, 2012
- Ganglion Cell Loss in Relation to Visual Disability in Multiple SclerosisOphthalmology, 2012
- Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for NeurodegenerationNeurotherapeutics, 2011
- Detection of retinal changes in Parkinson's disease with spectral-domain optical coherence tomographyClinical Ophthalmology, 2010
- Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosisAnnals of Neurology, 2010
- Distal axonopathy with structural persistence in glaucomatous neurodegenerationProceedings of the National Academy of Sciences of the United States of America, 2010
- Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse modelJournal of Biomedical Optics, 2010
- Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathiesNeurology, 2009
- Optical coherence tomography: a window into the mechanisms of multiple sclerosisNature Clinical Practice Neurology, 2008