Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications
Open Access
- 28 September 2019
- journal article
- review article
- Published by MDPI AG in Marine Drugs
- Vol. 17 (10), 556
- https://doi.org/10.3390/md17100556
Abstract
Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from B. bifurcata is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and in chemico assays already performed to assess different biological activities attributed to B. bifurcata diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of B. bifurcata diterpenes for high-value applications are critically discussed.Keywords
Funding Information
- European Regional Development Fund (AgroForWealth: Biorefining of agricultural and forest by-products and wastes: integrated strategic for valorization of resources towards society wealth and sustainability (CENTRO-01-0145-FEDER-000001)
This publication has 60 references indexed in Scilit:
- Advances in the extraction of natural ingredients by high pressure extraction technologyTrends in Food Science & Technology, 2013
- Biosynthesis, characterization and antimicrobial activity of copper oxide nanoparticles (CONPs) produced using brown alga extract (Bifurcaria bifurcata)Applied Nanoscience, 2013
- Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparumMarine Drugs, 2013
- Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug developmentNew Biotechnology, 2012
- Further eleganolone-derived diterpenes from the brown alga Bifurcaria bifurcataTetrahedron Letters, 2012
- Antiprotozoal Activities of Organic Extracts from French Marine SeaweedsMarine Drugs, 2011
- Antimycobacterial, antiprotozoal and cytotoxic potential of twenty‐one brown algae (phaeophyceae) from British and Irish watersPhytotherapy Research, 2010
- Phlorotannins from Ecklonia cava (Phaeophyceae): Biological activities and potential health benefitsBioFactors, 2010
- Antiprotozoal, antimycobacterial and cytotoxic potential of some british green algaePhytotherapy Research, 2010
- Effect of different conditioning treatments on total phenolic content and antioxidant activities in two Sargassacean species: Comparison of the frondose Sargassum muticum (Yendo) Fensholt and the cylindrical Bifurcaria bifurcata R. RossPhycological Research, 2008