Small studies may overestimate the effect sizes in critical care meta-analyses: a meta-epidemiological study
Open Access
- 1 January 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Critical Care
- Vol. 17 (1), R2
- https://doi.org/10.1186/cc11919
Abstract
Small-study effects refer to the fact that trials with limited sample sizes are more likely to report larger beneficial effects than large trials. However, this has never been investigated in critical care medicine. Thus, the present study aimed to examine the presence and extent of small-study effects in critical care medicine.This publication has 41 references indexed in Scilit:
- Vasopressin and terlipressin in adult vasodilatory shock: a systematic review and meta-analysis of nine randomized controlled trialsCritical Care, 2012
- Pressure and Volume Limited Ventilation for the Ventilatory Management of Patients with Acute Lung Injury: A Systematic Review and Meta-AnalysisPLOS ONE, 2011
- An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injuryCritical Care, 2011
- Prevention of ventilator-associated pneumonia, mortality and all intensive care unit acquired infections by topically applied antimicrobial or antiseptic agents: a meta-analysis of randomized controlled trials in intensive care unitsCritical Care, 2011
- Effect of Glucose—Insulin—Potassium Infusion on Mortality in Critical Care Settings: A Systematic Review and Meta‐AnalysisThe Journal of Clinical Pharmacology, 2009
- Does a Higher Positive End Expiratory Pressure Decrease Mortality in Acute Respiratory Distress Syndrome?Anesthesiology, 2009
- Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological studyBMJ, 2008
- Antithrombin III in critically ill patients: systematic review with meta-analysis and trial sequential analysisBMJ, 2007
- Multivariable modelling for meta‐epidemiological assessment of the association between trial quality and treatment effects estimated in randomized clinical trialsStatistics in Medicine, 2006
- Statistical methods for assessing the influence of study characteristics on treatment effects in ‘meta‐epidemiological’ researchStatistics in Medicine, 2002