Biomimetic Mineralization and Bioactivity of Phosphorylated Chitosan
- 1 June 2005
- journal article
- Published by Trans Tech Publications, Ltd. in Key Engineering Materials
- Vol. 288-289, 429-432
- https://doi.org/10.4028/www.scientific.net/kem.288-289.429
Abstract
Phosphorylated chitosans were synthesized as templates to manipulate hydroxyapatite (HA) crystal nucleation, growth and microstructure. Two kinds of insoluble phosphorylated chitosan were soaked in saturated Ca(OH)2 solution for 4 d and in 1.5× SBF (simulated body fluid) solutions for 14 d at 37 °C for biomimetic mineralization. A lower [P]-content of phosphorylated chitosan promoted greater mineralization than higher [P]-content. Phosphorylated chitosan inhibited osteoblast proliferation and differentiation in vitro, while calcium phosphate phosphorylated chitosan composites did not.Keywords
This publication has 12 references indexed in Scilit:
- Cellulose phosphates as biomaterials. Mineralization of chemically modified regenerated cellulose hydrogelsJournal of Materials Science, 2001
- Bioactive Properties of Chitin/Chitosan—Calcium Phosphate Composite MaterialsJournal of Sol-Gel Science and Technology, 2001
- Porous calcium phosphate coating over phosphorylated chitosan film by a biomimetic methodBiomaterials, 1999
- Molecular Manipulation of Microstructures: Biomaterials, Ceramics, and SemiconductorsScience, 1997
- The negative side of crystal growthNature, 1997
- Further studies of calcium phosphate growth on phosphorylated cotton fibresJournal of Materials Science: Materials in Medicine, 1995
- Growth of calcium phosphate on surface-modified cottonJournal of Materials Science: Materials in Medicine, 1995
- In vitro hydroxyapatite deposition onto a film surface‐grafted with organophosphate polymerJournal of Biomedical Materials Research, 1994
- Molecular recognition in biomineralizationNature, 1988
- Highly phosphorylated derivatives of chitin, partially deacetylated chitin and chitosan as new functional polymers: preparation and characterizationInternational Journal of Biological Macromolecules, 1986