Flow Residence Time and Regions of Intraluminal Thrombus Deposition in Intracranial Aneurysms
Open Access
- 25 May 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Annals of Biomedical Engineering
- Vol. 38 (10), 3058-3069
- https://doi.org/10.1007/s10439-010-0065-8
Abstract
Thrombus formation in intracranial aneurysms, while sometimes stabilizing lesion growth, can present additional risk of thrombo-embolism. The role of hemodynamics in the progression of aneurysmal disease can be elucidated by patient-specific computational modeling. In our previous work, patient-specific computational fluid dynamics (CFD) models were constructed from MRI data for three patients who had fusiform basilar aneurysms that were thrombus-free and then proceeded to develop intraluminal thrombus. In this study, we investigated the effect of increased flow residence time (RT) by modeling passive scalar advection in the same aneurysmal geometries. Non-Newtonian pulsatile flow simulations were carried out in base-line geometries and a new postprocessing technique, referred to as “virtual ink” and based on the passive scalar distribution maps, was used to visualize the flow and estimate the flow RT. The virtual ink technique clearly depicted regions of flow separation. The flow RT at different locations adjacent to aneurysmal walls was calculated as the time the virtual ink scalar remained above a threshold value. The RT values obtained in different areas were then correlated with the location of intra-aneurysmal thrombus observed at a follow-up MR study. For each patient, the wall shear stress (WSS) distribution was also obtained from CFD simulations and correlated with thrombus location. The correlation analysis determined a significant relationship between regions where CFD predicted either an increased RT or low WSS and the regions where thrombus deposition was observed to occur in vivo. A model including both low WSS and increased RT predicted thrombus-prone regions significantly better than the models with RT or WSS alone.Keywords
This publication has 28 references indexed in Scilit:
- Aneurysm Growth Occurs at Region of Low Wall Shear StressStroke, 2008
- Numerical Modeling of the Flow in Intracranial Aneurysms: Prediction of Regions Prone to Thrombus FormationAnnals of Biomedical Engineering, 2008
- Numerical Simulations of Flow in Cerebral Aneurysms: Comparison of CFD Results and In Vivo MRI MeasurementsJournal of Biomechanical Engineering, 2008
- Intracranial and Abdominal Aortic Aneurysms: Similarities, Differences, and Need for a New Class of Computational ModelsAnnual Review of Biomedical Engineering, 2008
- Wall Shear Stress on Ruptured and Unruptured Intracranial Aneurysms at the Internal Carotid ArteryAmerican Journal of Neuroradiology, 2008
- Characterization of Coherent Structures in the Cardiovascular SystemAnnals of Biomedical Engineering, 2008
- Spatial comparison between wall shear stress measures and porcine arterial endothelial permeabilityAmerican Journal of Physiology-Heart and Circulatory Physiology, 2004
- Dynamics of Blood Flow and Platelet Transport in Pathological VesselsAnnals of the New York Academy of Sciences, 2004
- The Role of Fluid Mechanics in the Localization and Detection of AtherosclerosisJournal of Biomechanical Engineering, 1993
- Shear-induced activation of plateletsJournal of Biomechanics, 1979