Phenobarbitone modulation of postsynaptic GABA receptor function on cultured mammalian neurons
- 31 December 1979
- journal article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 206 (1164), 319-327
- https://doi.org/10.1098/rspb.1979.0108
Abstract
The anticonvulsant barbiturate phenobarbitone increases membrane current and conductance responses to $\gamma $-aminobutyric acid (GABA) in cultured mouse spinal neurons. Analyses of GABA current fluctuations under control conditions and in the presence of phenobarbitone show that the principle action is to increase the average time during which GABA-activated channels remain open. The duration of miniature synaptic currents with a time constant of decay similar to the mean open-time of GABA-activated channels is prolonged by the drug. The results suggest that (1) the synaptic events are GABA-mediated and (2) the enhancement of these events by barbiturate is due to the postsynaptic action of the drug.Keywords
This publication has 8 references indexed in Scilit:
- GABA and glycine may share the same conductance channel on cultured mammalian neuronesNature, 1979
- GABA-induced conductance fluctuations in cultured spinal neuronesNature, 1978
- Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic propertiesJournal of Neurophysiology, 1977
- Barbiturate reversal of amino acid antagonism produced by convulsant agentsNature, 1976
- Pentobarbital selectively enhances GABA-mediated post-synaptic inhibition in tissue cultured mouse spinal neuronsBrain Research, 1976
- Prolongation of hippocampal inhibitory postsynaptic potentials by barbituratesNature, 1975
- Pentobarbital: action on frog motoneuronsBrain Research, 1975
- Presynaptic action of barbiturates in the frog spinal cord.Proceedings of the National Academy of Sciences of the United States of America, 1975