Sporadic Sclerotic Fibroma of the Oral Soft Tissues
- 1 June 2004
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Dermatopathology
- Vol. 26 (3), 182-187
- https://doi.org/10.1097/00000372-200406000-00002
Abstract
Sclerotic fibroma (SF) is an uncommon, benign fibrous neoplasm that may present either as a sporadic, small, solitary cutaneous mass, in otherwise healthy individuals, or as solitary or multiple, discrete skin nodules in patients with Cowden syndrome. Oral SF has been reported in patients with Cowden syndrome; however we now report the first documented series of sporadic SF originating within the oral mucosa. We describe 5 cases of SF arising in 3 women and 2 men with an age range of 43 to 66 years. The buccal mucosa was the site of involvement in 4 patients and the lower lip in 1 patient. Microscopically, each of the tumors was characterized by an unencapsulated, well-circumscribed, hypocellular submucosal nodule that was sharply demarcated from the surrounding tissues. The neoplasms were primarily composed of thick collagen bundles that were occasionally arranged in a storiform pattern. Prominent clefts separated many of the collagen bundles. In all cases, spindle and stellate-shaped cells containing fusiform or stellate-shaped nuclei and inconspicuous nucleoli were found scattered throughout the lesion. Occasional stellate-shaped, multinucleated cells were also seen. Many of the cells also exhibited long dendritic cytoplasmic processes. The tumor cells strongly expressed CD34 and vimentin, and occasionally factor XIIIa, but were negative for markers of myofibroblastic, neural or melanocytic differentiation. These findings confirm that oral SF represents a unique entity and should be differentiated from more commonly occurring benign fibrous lesions of the oral soft tissues.Keywords
This publication has 33 references indexed in Scilit:
- Ultrastructural and immunohistochemical characterization of the so‐called giant multinucleate cells in cutaneous collagenomasHistopathology, 2002
- Strahleninduzierte kutane Hamartome bei einer Patientin mit Cowden-SyndromDie Dermatologie, 2002
- Cowden Syndrome – Diagnostic Skin SignsDermatology, 2001
- Expression of CD34 in Sclerotic (“Plywood”) FibromasThe American Journal of Dermatopathology, 2000
- Solitary Sclerotic Fibroma of the SkinThe American Journal of Dermatopathology, 2000
- Giant Cell CollagenomaThe American Journal of Surgical Pathology, 1998
- Phenotypic characterisation of stellate and giant cells in giant cell fibroma by immunocytochemistryJournal of Oral Pathology & Medicine, 1994
- Sclerotic fibromas of the skinJournal of the American Academy of Dermatology, 1989