Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy
- 1 January 2011
- journal article
- research article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 21 (1), 387-393
- https://doi.org/10.1016/j.bmcl.2010.10.134
Abstract
No abstract availableKeywords
Funding Information
- Robert A. Welch Foundation (N-0871)
- Veterans Affairs Merit Review Program, GRECC
- NIH (R01 AI063517-01)
- NIH (R01 AI062968)
- NIH (R01 GM54072)
This publication has 33 references indexed in Scilit:
- Diversity, Epidemiology, and Genetics of Class D β-LactamasesAntimicrobial Agents and Chemotherapy, 2010
- Role of E166 in the Imine to Enamine Tautomerization of the Clinical β-Lactamase Inhibitor SulbactamBiochemistry, 2009
- Regiospecific Syntheses of 6α-(1R-Hydroxyoctyl)penicillanic Acid and 6β-(1R-Hydroxyoctyl)penicillanic Acid as Mechanistic Probes of Class D β-LactamasesOrganic Letters, 2009
- Extended-Spectrum Cephalosporinases in Pseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 2009
- The penicillin-binding proteins: structure and role in peptidoglycan biosynthesisFEMS Microbiology Reviews, 2008
- The continuing challenge of ESBLsCurrent Opinion in Pharmacology, 2007
- Carbapenemases: the Versatile β-LactamasesClinical Microbiology Reviews, 2007
- The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance 1 1Edited by R. HuberJournal of Molecular Biology, 2000
- Crystal Structure of 6α-(Hydroxymethyl)penicillanate Complexed to the TEM-1 β-Lactamase from Escherichia coli: Evidence on the Mechanism of Action of a Novel Inhibitor Designed by a Computer-Aided ProcessJournal of the American Chemical Society, 1996
- Studies on penicillinase produced by a strain of Staphylococcus aureusProceedings of the Royal Society of London. B. Biological Sciences, 1963