The golden age: gold nanoparticles for biomedicine
Top Cited Papers
- 22 November 2011
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 41 (7), 2740-2779
- https://doi.org/10.1039/c1cs15237h
Abstract
Gold nanoparticles have been used in biomedical applications since their first colloidal syntheses more than three centuries ago. However, over the past two decades, their beautiful colors and unique electronic properties have also attracted tremendous attention due to their historical applications in art and ancient medicine and current applications in enhanced optoelectronics and photovoltaics. In spite of their modest alchemical beginnings, gold nanoparticles exhibit physical properties that are truly different from both small molecules and bulk materials, as well as from other nanoscale particles. Their unique combination of properties is just beginning to be fully realized in range of medical diagnostic and therapeutic applications. This critical review will provide insights into the design, synthesis, functionalization, and applications of these artificial molecules in biomedicine and discuss their tailored interactions with biological systems to achieve improved patient health. Further, we provide a survey of the rapidly expanding body of literature on this topic and argue that gold nanotechnology-enabled biomedicine is not simply an act of ‘gilding the (nanomedicinal) lily’, but that a new ‘Golden Age’ of biomedical nanotechnology is truly upon us. Moving forward, the most challenging nanoscience ahead of us will be to find new chemical and physical methods of functionalizing gold nanoparticles with compounds that can promote efficient binding, clearance, and biocompatibility and to assess their safety to other biological systems and their long-term term effects on human health and reproduction (472 references).Keywords
This publication has 184 references indexed in Scilit:
- Luminescent Gold Nanoparticles with Efficient Renal ClearanceAngewandte Chemie, 2011
- Drug Delivery Using Nanoparticle‐Stabilized NanocapsulesAngewandte Chemie, 2010
- Intra-organ biodistribution of gold nanoparticles using intrinsic two-photon-induced photoluminescenceLasers in Surgery and Medicine, 2010
- Near‐Infrared Light Triggers Release of Paclitaxel from Biodegradable Microspheres: Photothermal Effect and Enhanced Antitumor ActivitySmall, 2010
- Gold Nanocages as Photothermal Transducers for Cancer TreatmentSmall, 2010
- Near‐Infrared‐Resonant Gold/Gold Sulfide Nanoparticles as a Photothermal Cancer Therapeutic AgentSmall, 2010
- Nanotechnology‐based molecular photoacoustic and photothermal flow cytometry platform for in‐vivo detection and killing of circulating cancer stem cellsJournal of Biophotonics, 2009
- SERS‐Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near‐Infrared Imaging and Photothermal HeatingAdvanced Materials, 2009
- Biodegradable Plasmon Resonant NanoshellsAdvanced Materials, 2008
- Gold Nanorods Mediate Tumor Cell Death by Compromising Membrane IntegrityAdvanced Materials, 2007